A Tool to Change Human Antigen R Protein Expression: May Have Implications in both Cancer & Diabetes >

 

Copyright © 2014 by Dr. Kerry Masterson  ·  All Rights reserved  ·  E-Mail: km@humanantigenr.com
 
 

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Human Antigen R mRNA Protective Sequence Site
 
                                              
                                                cFMS   COX-2   GATA3   HER2   Protein A   P53   WNT5A


Pub Med Search for Tumorigenesis


1: Arechederra M, Priego N, Vazquez-Carballo A, Sequera C, Gutierrez-Uzquiza A, Cerezo-Guisado MI, Ortiz-Rivero S, Roncero C, Cuenda A, Guerrero C, Porras A. p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences. Role in migration and invasion. J Biol Chem. 2014 Dec 29. pii: jbc.M114.582239. [Epub ahead of print] PubMed PMID: 25548290.

2: Kim I, Hur J, Jeong S. HuR represses Wnt/β-catenin-mediated transcriptional activity by promoting cytoplasmic localization of β-catenin. Biochem Biophys Res Commun. 2014 Dec 19. pii: S0006-291X(14)02218-9. doi: 10.1016/j.bbrc.2014.12.052.[Epub ahead of print] PubMed PMID: 25534855.

3: Vreeland AC, Levi L, Zhang W, Berry DC, Noy N. Cellular Retinoic Acid-binding Protein 2 Inhibits Tumor Growth by Two Distinct Mechanisms. J Biol Chem. 2014 Dec 5;289(49):34065-73. doi: 10.1074/jbc.M114.604041. Epub 2014 Oct 15. PubMed PMID: 25320093; PubMed Central PMCID: PMC4256341.

4: Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res. 2014 Sep 15;74(18):5322-35. doi: 10.1158/0008-5472.CAN-14-0726. Epub 2014 Aug 1. PubMed PMID: 25085247;
PubMed Central PMCID: PMC4167566.

5: Hung CM, Huang WC, Pan HL, Chien PH, Lin CW, Chen LC, Chien YF, Lin CC, Leow KH, Chen WS, Chen JY, Ho CY, Hou PS, Chen YJ. Hepatitis B virus X upregulates HuR protein level to stabilize HER2 expression in hepatocellular carcinoma cells. Biomed Res Int. 2014;2014:827415. doi: 10.1155/2014/827415. Epub 2014 Feb 27.
PubMed PMID: 24719890; PubMed Central PMCID: PMC3955687.

6: Krishnan N, Titus MA, Thapar R. The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins. PLoS One. 2014 Jan 9;9(1):e85427. doi: 10.1371/journal.pone.0085427. eCollection 2014. PubMed PMID: 24416409; PubMed Central PMCID: PMC3887067.

7: Balkhi MY, Iwenofu OH, Bakkar N, Ladner KJ, Chandler DS, Houghton PJ, London CA, Kraybill W, Perrotti D, Croce CM, Keller C, Guttridge DC. miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. Sci Signal. 2013 Jul 30;6(286):ra63. doi: 10.1126/scisignal.2004177. Erratum in: Sci Signal. 2013 Sep 10;6(292):er6. Balkhi, Mumtaz Y [corrected to Balkhi, M Y]. PubMed PMID: 23901138; PubMed Central PMCID: PMC3885907.

8: Cha JD, Kim HK, Cha IH. Cytoplasmic HuR expression: correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells. Head Neck. 2014 Aug;36(8):1168-75. doi:10.1002/hed.23431. Epub 2014 Jan 16. PubMed PMID: 23852810.

9: Sun DP, Lin CY, Tian YF, Chen LT, Lin LC, Lee SW, Hsing CH, Lee HH, Shiue YL, Huang HY, Li CF, Liang PI. Clinicopathological significance of HuR expression in gallbladder carcinoma: with special emphasis on the implications of its nuclear and cytoplasmic expression. Tumour Biol. 2013 Oct;34(5):3059-69. doi:
10.1007/s13277-013-0872-2. Epub 2013 May 31. PubMed PMID: 23722602.

10: Liang PI, Li WM, Wang YH, Wu TF, Wu WR, Liao AC, Shen KH, Wei YC, Hsing CH,Shiue YL, Huang HY, Hsu HP, Chen LT, Lin CY, Tai C, Lin CM, Li CF. HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma. BMC Cancer. 2012 Dec 21;12:611. doi: 10.1186/1471-2407-12-611. PubMed PMID: 23259573; PubMed Central
PMCID: PMC3571926.

11: Vo DT, Abdelmohsen K, Martindale JL, Qiao M, Tominaga K, Burton TL, Gelfond JA, Brenner AJ, Patel V, Trageser D, Scheffler B, Gorospe M, Penalva LO. The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells. Mol Cancer Res. 2012 Jan;10(1):143-55. doi: 10.1158/1541-7786.MCR-11-0208. PubMed PMID: 22258704; PubMed Central PMCID:
PMC3265026.

12: Embade N, Fernández-Ramos D, Varela-Rey M, Beraza N, Sini M, Gutiérrez de Juan V, Woodhoo A, Martínez-López N, Rodríguez-Iruretagoyena B, Bustamante FJ, de la Hoz AB, Carracedo A, Xirodimas DP, Rodríguez MS, Lu SC, Mato JM, Martínez-Chantar ML. Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology. 2012 Apr;55(4):1237-48. doi: 10.1002/hep.24795. Epub 2012 Mar 1. PubMed PMID: 22095636; PubMed Central PMCID: PMC3298572.

13: Baou M, Norton JD, Murphy JJ. AU-rich RNA binding proteins in hematopoiesis and leukemogenesis. Blood. 2011 Nov 24;118(22):5732-40. doi: 10.1182/blood-2011-07-347237. Epub 2011 Sep 13. PubMed PMID: 21917750.

14: Trojanowicz B, Dralle H, Hoang-Vu C. AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders. Thyroid Res. 2011 Aug 3;4 Suppl 1:S5. doi: 10.1186/1756-6614-4-S1-S5. PubMed PMID: 21835052; PubMed Central PMCID: PMC3155111.

15: Whelan JT, Hollis SE, Cha DS, Asch AS, Lee MH. Post-transcriptional regulation of the Ras-ERK/MAPK signaling pathway. J Cell Physiol. 2012 Mar;227(3):1235-41. doi: 10.1002/jcp.22899. Review. PubMed PMID: 21688267.

16: Chae KS, Kang MJ, Lee JH, Ryu BK, Lee MG, Her NG, Ha TK, Han J, Kim YK, Chi SG. Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions. Oncogene. 2011 Mar 10;30(10):1213-28. doi:10.1038/onc.2010.498. Epub 2010 Nov 8. PubMed PMID: 21057546.

17: Cha JD, Li S, Cha IH. Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. Head Neck. 2011 May;33(5):627-37. doi: 10.1002/hed.21507. Epub 2010 Oct 19. PubMed PMID: 20960565.

18: Abdelmohsen K, Kim MM, Srikantan S, Mercken EM, Brennan SE, Wilson GM, CaboRd, Gorospe M. miR-519 suppresses tumor growth by reducing HuR levels. Cell Cycle. 2010 Apr 1;9(7):1354-9. Epub 2010 Apr 1. PubMed PMID: 20305372; PubMed Central PMCID: PMC3057889.

19: López de Silanes I, Gorospe M, Taniguchi H, Abdelmohsen K, Srikantan S,Alaminos M, Berdasco M, Urdinguio RG, Fraga MF, Jacinto FV, Esteller M. The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA. Nucleic Acids Res. 2009 May;37(8):2658-71. doi: 10.1093/nar/gkp123. Epub 2009 Mar 6. PubMed PMID: 19270063; PubMed Central PMCID: PMC2677878.

20: Al-Ahmadi W, Al-Haj L, Al-Mohanna FA, Silverman RH, Khabar KS. RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth. Oncogene. 2009 Apr 16;28(15):1782-91. doi: 10.1038/onc.2009.16. Epub 2009 Mar 2. PubMed PMID: 19252527; PubMed Central PMCID: PMC3071643.

21: Young LE, Sanduja S, Bemis-Standoli K, Pena EA, Price RL, Dixon DA. The mRNA  binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. Gastroenterology. 2009 May;136(5):1669-79. doi: 10.1053/j.gastro.2009.01.010. Epub 2009 Jan 15. PubMed PMID: 19208339; PubMed Central PMCID: PMC3742387.

22: Kang MJ, Ryu BK, Lee MG, Han J, Lee JH, Ha TK, Byun DS, Chae KS, Lee BH, Chun HS, Lee KY, Kim HJ, Chi SG. NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis. Gastroenterology. 2008 Dec;135(6):2030-42, 2042.e1-3. doi:
10.1053/j.gastro.2008.08.009. Epub 2008 Aug 20. PubMed PMID: 18824170.

23: Winter J, Roepcke S, Krause S, Müller EC, Otto A, Vingron M, Schweiger S. Comparative 3'UTR analysis allows identification of regulatory clusters that drive Eph/ephrin expression in cancer cell lines. PLoS One. 2008 Jul 23;3(7):e2780. doi: 10.1371/journal.pone.0002780. PubMed PMID: 18648668; PubMed Central PMCID: PMC2474680.


24: Brosens LA, Keller JJ, Pohjola L, Haglund C, Morsink FH, Iacobuzio-Donahue C, Goggins M, Giardiello FM, Ristimäki A, Offerhaus GJ. Increased expression of cytoplasmic HuR in familial adenomatous polyposis. Cancer Biol Ther. 2008Mar;7(3):424-7. Epub 2007 Dec 13. PubMed PMID: 18094611.

25: Yuen JS, Cockman ME, Sullivan M, Protheroe A, Turner GD, Roberts IS, Pugh CW, Werner H, Macaulay VM. The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma. Oncogene. 2007 Oct 4;26(45):6499-508. Epub 2007 May 7. PubMed PMID: 17486080.

26: Lee HK, Jeong S. Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. Nucleic Acids Res. 2006;34(19):5705-14. Epub 2006 Oct 12. PubMed PMID: 17040897; PubMed Central PMCID: PMC1636482.

27: López de Silanes I, Fan J, Galbán CJ, Spencer RG, Becker KG, Gorospe M. Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity. Gene Expr. 2004;12(1):49-59. PubMed PMID: 15473260.

28: Sengupta S, Jang BC, Wu MT, Paik JH, Furneaux H, Hla T. The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. J Biol Chem. 2003 Jul 4;278(27):25227-33. Epub 2003 Apr 18. PubMed PMID: 12704185.