A Tool to Change Human Antigen R Protein Expression: May Have Implications in both Cancer & Diabetes >


Copyright © 2014 by Dr. Kerry Masterson  ·  All Rights reserved  ·  E-Mail: km@humanantigenr.com

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Human Antigen R mRNA Protective Sequence Site
A ssDNA Poly-microRNA Antagonist deregulates Human Antigen R (HuR) Expression and Inhibits AKTSER473
Phosphorylation in Prostate and other Cancers.

PubMed search for HuR AND Prostate

Hur knock-down reduced PC3 growth and migration.

1: Griseri P, Pagès G. Control of pro-angiogenic cytokine mRNA half-life in cancer: the role of AU-rich elements and associated proteins. J Interferon Cytokine Res. 2014 Apr;34(4):242-54. doi: 10.1089/jir.2013.0140. Review. PubMed
PMID: 24697202.

2: Krishnan N, Titus MA, Thapar R. The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins. PLoS One. 2014 Jan 9;9(1):e85427. doi: 10.1371/journal.pone.0085427. eCollection
2014. PubMed PMID: 24416409; PubMed Central PMCID: PMC3887067.

3: Vanella L, Di Giacomo C, Acquaviva R, Barbagallo I, Cardile V, Kim DH, Abraham NG, Sorrenti V. Apoptotic markers in a prostate cancer cell line: effect of ellagic acid. Oncol Rep. 2013 Dec;30(6):2804-10. doi: 10.3892/or.2013.2757. Epub
2013 Sep 30. PubMed PMID: 24085108.

4: Chu PC, Kulp SK, Chen CS. Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energyrestriction-mimetic agent. Carcinogenesis. 2013 Dec;34(12):2694-705. doi:10.1093/carcin/bgt251. Epub 2013 Jul 16. PubMed PMID: 23864387; PubMed Central PMCID: PMC3845891.

5: Epis MR, Barker A, Giles KM, Beveridge DJ, Leedman PJ. The RNA-binding protein HuR opposes the repression of ERBB-2 gene expression by microRNA miR-331-3p in prostate cancer cells. J Biol Chem. 2011 Dec 2;286(48):41442-54. doi:
10.1074/jbc.M111.301481. Epub 2011 Oct 4. PubMed PMID: 21971048; PubMed Central PMCID: PMC3308856.

6: Chae KS, Kang MJ, Lee JH, Ryu BK, Lee MG, Her NG, Ha TK, Han J, Kim YK, ChiSG. Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions. Oncogene. 2011 Mar 10;30(10):1213-28. doi:
10.1038/onc.2010.498. Epub 2010 Nov 8. PubMed PMID: 21057546.

7: Kojima K, Fujita Y, Nozawa Y, Deguchi T, Ito M. MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms. Prostate. 2010 Oct 1;70(14):1501-12. doi:
10.1002/pros.21185. PubMed PMID: 20687223.

8: Brennan SE, Kuwano Y, Alkharouf N, Blackshear PJ, Gorospe M, Wilson GM. The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. Cancer Res. 2009 Jun
15;69(12):5168-76. doi: 10.1158/0008-5472.CAN-08-4238. Epub 2009 Jun 2. PubMed PMID: 19491267; PubMed Central PMCID: PMC2724875.

9: Kandasamy K, Kraft AS. Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3'-untranslated region. Mol Cancer Ther. 2008 May;7(5):1091-100. doi: 10.1158/1535-7163.MCT-07-2368.
PubMed PMID: 18483298; PubMed Central PMCID: PMC3632452.

10: Barbisan F, Mazzucchelli R, Santinelli A, Lopez-Beltran A, Cheng L, Scarpelli M, Montorsi F, Montironi R. Overexpression of ELAV-like protein HuR is associated with increased COX-2 expression in atrophy, high-grade prostatic intraepithelial
neoplasia, and incidental prostate cancer in cystoprostatectomies. Eur Urol. 2009 Jul;56(1):105-12. doi: 10.1016/j.eururo.2008.04.043. Epub 2008 Apr 30. PubMed PMID: 18468781.

11: Niesporek S, Kristiansen G, Thoma A, Weichert W, Noske A, Buckendahl AC, JungK, Stephan C, Dietel M, Denkert C. Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2
expression. Int J Oncol. 2008 Feb;32(2):341-7. PubMed PMID: 18202756.

12: Quann EJ, Khwaja F, Djakiew D. The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells. Cancer Res. 2007 Dec 1;67(23):11402-10. PubMed PMID: 18056468.

13: Annabi B, Bouzeghrane M, Currie JC, Dulude H, Daigneault L, Garde S, Rabbani SA, Panchal C, Wu JJ, Béliveau R. Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin
receptor signaling. Anticancer Drugs. 2006 Apr;17(4):429-38. PubMed PMID:16550001.

14: Yeap BB, Voon DC, Vivian JP, McCulloch RK, Thomson AM, Giles KM,Czyzyk-Krzeska MF, Furneaux H, Wilce MC, Wilce JA, Leedman PJ. Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA. J Biol Chem. 2002 Jul 26;277(30):27183-92. Epub 2002 May 13. PubMed PMID: 12011088.