A Tool to Change Human Antigen R Protein Expression: May Have Implications in both Cancer & Diabetes >


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Human Antigen R mRNA Protective Sequence Site
PubMed search HuR AND Colon Cancer

1: Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small
intestinal and colonic tumor development. Cancer Res. 2014 Sep 15;74(18):5322- doi: 10.1158/0008-5472.CAN-14-0726. Epub 2014 Aug 1. PubMed PMID: 25085247;PubMed Central PMCID: PMC4167566.

2: Winkler C, Doller A, Imre G, Badawi A, Schmid T, Schulz S, Steinmeyer N, Pfeilschifter J, Rajalingam K, Eberhardt W. Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by
increasing the translation of caspase-2L. Cell Death Dis. 2014 Jul 10;5:e1321. doi: 10.1038/cddis.2014.279. PubMed PMID: 25010987; PubMed Central PMCID: PMC4123073.

3: Akaike Y, Masuda K, Kuwano Y, Nishida K, Kajita K, Kurokawa K, Satake Y, Shoda K, Imoto I, Rokutan K. HuR regulates alternative splicing of the TRA2β gene in human colon cancer cells under oxidative stress. Mol Cell Biol. 2014
Aug;34(15):2857-73. doi: 10.1128/MCB.00333-14. Epub 2014 May 27. PubMed PMID:24865968; PubMed Central PMCID: PMC4135568.

4: Griseri P, Pagès G. Control of pro-angiogenic cytokine mRNA half-life in cancer: the role of AU-rich elements and associated proteins. J Interferon Cytokine Res. 2014 Apr;34(4):242-54. doi: 10.1089/jir.2013.0140. Review. PubMed PMID: 24697202.

5: Sharma A, Bhat AA, Krishnan M, Singh AB, Dhawan P. Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. Carcinogenesis. 2013 Nov;34(11):2610-21.
doi: 10.1093/carcin/bgt207. Epub 2013 Jul 23. PubMed PMID: 23880304; PubMed Central PMCID: PMC3810835.

6: Murakami A, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis. Biofactors. 2013 Mar-Apr;39(2):221-32. doi: 10.1002/biof.1054. Epub 2012 Dec 11. PubMed PMID: 23233214.

7: Kim I, Kwak H, Lee HK, Hyun S, Jeong S. β-Catenin recognizes a specific RNA  motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells. Nucleic Acids Res. 2012 Aug;40(14):6863-72. doi: 10.1093/nar/gks331. Epub
2012 Apr 27. PubMed PMID: 22544606; PubMed Central PMCID: PMC3413138.

8: Park SH, Choi HJ, Yang H, Do KH, Kim J, Kim HH, Lee H, Oh CG, Lee DW, Moon Y. Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1. J Biol Chem. 2012
Jun 8;287(24):19841-55. doi: 10.1074/jbc.M111.330639. Epub 2012 Apr 17. PubMedPMID: 22511768; PubMed Central PMCID: PMC3370169.

9: Yamakuchi M. MicroRNA Regulation of SIRT1. Front Physiol. 2012 Mar 30;3:68. doi: 10.3389/fphys.2012.00068. eCollection 2012. PubMed PMID: 22479251; PubMed Central PMCID: PMC3315824.

10: Lauriola L, Granone P, Ramella S, Lanza P, Ranelletti FO. Expression of the RNA-binding protein HuR and its clinical significance in human stage I and II lung adenocarcinoma. Histol Histopathol. 2012 May;27(5):617-26. PubMed PMID:

11: McLarnon A. Cancer: Mdm2-regulated stabilization of HuR by neddylation in HCC and colon cancer--a possible target for therapy. Nat Rev Gastroenterol Hepatol. 2011 Dec 13;9(1):4. doi: 10.1038/nrgastro.2011.241. PubMed PMID: 22158377.

12: Embade N, Fernández-Ramos D, Varela-Rey M, Beraza N, Sini M, Gutiérrez de Juan V, Woodhoo A, Martínez-López N, Rodríguez-Iruretagoyena B, Bustamante FJ, de la Hoz AB, Carracedo A, Xirodimas DP, Rodríguez MS, Lu SC, Mato JM,
Martínez-Chantar ML. Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology. 2012 Apr;55(4):1237-48. doi: 10.1002/hep.24795. Epub 2012 Mar 1. PubMed PMID:
22095636; PubMed Central PMCID: PMC3298572.

13: Doller A, Winkler C, Azrilian I, Schulz S, Hartmann S, Pfeilschifter J, Eberhardt W. High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells. Carcinogenesis.2011 May;32(5):676-85. doi: 10.1093/carcin/bgr024. Epub 2011 Feb 10. PubMed PMID:21310943.

14: Xia M, Chen Y, Wang LC, Zandi E, Yang H, Bemanian S, Martínez-Chantar ML, Mato JM, Lu SC. Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants. J Biol Chem. 2010 Jun
25;285(26):20015-21. doi: 10.1074/jbc.M109.094821. Epub 2010 Apr 26. PubMed PMID: 20421296; PubMed Central PMCID: PMC2888413.

15: Lim SJ, Lee SH, Joo SH, Song JY, Choi SI. Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer. Cancer Res Treat. 2009 Jun;41(2):87-92. doi: 10.4143/crt.2009.41.2.87. Epub 2009 Jun 30. PubMed PMID:
19707506; PubMed Central PMCID: PMC2731207.

16: Strimpakos AS, Syrigos KN, Saif MW. Pharmacogenetics in pancreatic cancer. Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009. JOP. 2009 Jul 6;10(4):357-60. PubMed PMID: 19581734.

17: Young LE, Sanduja S, Bemis-Standoli K, Pena EA, Price RL, Dixon DA. The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. Gastroenterology. 2009 May;136(5):1669-79. doi:
10.1053/j.gastro.2009.01.010. Epub 2009 Jan 15. PubMed PMID: 19208339; PubMed Central PMCID: PMC3742387.

18: Abdelmohsen K, Srikantan S, Kuwano Y, Gorospe M. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20297-302. doi: 10.1073/pnas.0809376106. Epub 2008 Dec 16.
PubMed PMID: 19088191; PubMed Central PMCID: PMC2629338.

19: Brosens LA, Keller JJ, Pohjola L, Haglund C, Morsink FH, Iacobuzio-Donahue C, Goggins M, Giardiello FM, Ristimäki A, Offerhaus GJ. Increased expression of cytoplasmic HuR in familial adenomatous polyposis. Cancer Biol Ther. 2008
Mar;7(3):424-7. Epub 2007 Dec 13. PubMed PMID: 18094611.

20: Lim SJ, Kim HJ, Kim JY, Park K, Lee CM. Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma. Int J Gynecol Pathol. 2007 Jul;26(3):229-34. PubMed PMID: 17581403.

21: López de Silanes I, Lal A, Gorospe M. HuR: post-transcriptional paths to malignancy. RNA Biol. 2005 Jan;2(1):11-3. Epub 2005 Jan 19. PubMed PMID:17132932.

22: Lee HK, Jeong S. Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. Nucleic Acids Res. 2006;34(19):5705-14. Epub 2006 Oct 12. PubMed PMID: 17040897; PubMed Central PMCID: PMC1636482.

23: Denkert C, Koch I, von Keyserlingk N, Noske A, Niesporek S, Dietel M, Weichert W. Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. Mod Pathol. 2006 Sep;19(9):1261-9. Epub 2006 Jun 23. PubMed PMID: 16799479.

24: Sommer S, Cui Y, Brewer G, Fuqua SA. The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells. J Steroid Biochem Mol Biol. 2005 Nov;97(3):219-29. PubMed PMID: 16289864.

25: López de Silanes I, Fan J, Galbán CJ, Spencer RG, Becker KG, Gorospe M. Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity. Gene Expr. 2004;12(1):49-59. PubMed PMID: 15473260.

26: López de Silanes I, Fan J, Yang X, Zonderman AB, Potapova O, Pizer ES, Gorospe M. Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene.20 03 Oct 16;22(46):7146-54. PubMed PMID: 14562043.

27: Dixon DA, Tolley ND, King PH, Nabors LB, McIntyre TM, Zimmerman GA, Prescott SM. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Invest. 2001 Dec;108(11):1657-65. PubMed PMID: 11733561; PubMed Central PMCID: PMC200983.