A Tool to Change Human Antigen R Protein Expression: May Have Implications in both Cancer & Diabetes >


Copyright © 2014 by Dr. Kerry Masterson  ·  All Rights reserved  ·  E-Mail: km@humanantigenr.com

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Human Antigen R mRNA Protective Sequence Site
     HuR is involved with the Pharmacodynamics of:  Paclitaxel      Tamoxifen    Doxorubicin     Gemcitabine
PubMed Search for HuR and Clinc*     PubMed Search for HuR and Prognostic 

1: Kotta-Loizou I, Giaginis C, Theocharis S. Clinical significance of HuR expression in human malignancy. Med Oncol. 2014 Sep;31(9):161. doi: 10.1007/s12032-014-0161-y. Epub 2014 Aug 13. PubMed PMID: 25112469.

2: Wang J, Li D, Wang B, Wu Y. Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy. Breast Cancer Res Treat. 2013 Sep;141(2):213-24.
doi: 10.1007/s10549-013-2679-7. Epub 2013 Sep 14. PubMed PMID:  http://www.ncbi.nlm.nih.gov/pubmed/24036660.

3: Zhang C, Xue G, Bi J, Geng M, Chu H, Guan Y, Wang J, Wang B. Cytoplasmic expression of the ELAV-like protein HuR as a potential prognostic marker in esophageal squamous cell carcinoma. Tumour Biol. 2014 Jan;35(1):73-80. doi:
10.1007/s13277-013-1008-4. Epub 2013 Jul 20. PubMed PMID: 23873103.

4: Sun DP, Lin CY, Tian YF, Chen LT, Lin LC, Lee SW, Hsing CH, Lee HH, Shiue YL,  Huang HY, Li CF, Liang PI. Clinicopathological significance of HuR expression in gallbladder carcinoma: with special emphasis on the implications of its nuclear and cytoplasmic expression. Tumour Biol. 2013 Oct;34(5):3059-69. doi: 10.1007/s13277-013-0872-2. Epub 2013 May 31. PubMed PMID: 23722602.

5: Wang J, Guo Y, Chu H, Guan Y, Bi J, Wang B. Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis. Int J Mol Sci. 2013 May 10;14(5):10015-41. doi: 10.3390/ijms140510015. PubMed
PMID: 23665903; PubMed Central PMCID: PMC3676826.

6: Zhu Z, Wang B, Bi J, Zhang C, Guo Y, Chu H, Liang X, Zhong C, Wang J. Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer. Tumour Biol. 2013 Aug;34(4):2299-308. doi: 10.1007/s13277-013-0774-3. Epub 2013 Apr 19. PubMed PMID: 23605320.

7: Lauriola L, Serini S, Granone P, Lanza P, Martini M, Calviello G, Ranelletti FO. Hu/elav RNA-binding protein HuR regulates parathyroid hormone related peptide expression in human lung adenocarcinoma cells. Histol Histopathol. 2013
Sep;28(9):1205-16. Epub 2013 Apr 10. PubMed PMID: 23572284.

8: Miyata Y, Watanabe S, Sagara Y, Mitsunari K, Matsuo T, Ohba K, Sakai H. High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer. PLoS One. 2013;8(3):e59095. doi:
10.1371/journal.pone.0059095. Epub 2013 Mar 13. PubMed PMID: 23516604; PubMedCentral PMCID: PMC3596286.

9: Prislei S, Martinelli E, Mariani M, Raspaglio G, Sieber S, Ferrandina G, Shahabi S, Scambia G, Ferlini C. MiR-200c and HuR in ovarian cancer. BMC Cancer. 2013 Feb 8;13:72. doi: 10.1186/1471-2407-13-72. PubMed PMID: 23394580; PubMed
Central PMCID: PMC3576328.

10: Liang PI, Li WM, Wang YH, Wu TF, Wu WR, Liao AC, Shen KH, Wei YC, Hsing CH, Shiue YL, Huang HY, Hsu HP, Chen LT, Lin CY, Tai C, Lin CM, Li CF. HuR cytoplasmic expression is associated with increased cyclin A expression and poor
outcome with upper urinary tract urothelial carcinoma. BMC Cancer. 2012 Dec 21;12:611. doi: 10.1186/1471-2407-12-611. PubMed PMID: 23259573; PubMed Central PMCID: PMC3571926.

11: Upadhyay R, Sanduja S, Kaza V, Dixon DA. Genetic polymorphisms in RNA  proteins contribute to breast cancer survival. Int J Cancer. 2013 Feb1;132(3):E128-38. doi: 10.1002/ijc.27789. Epub 2012 Sep 18. PubMed PMID:22907529; PubMed Central PMCID: PMC3508313.

12: Lauriola L, Granone P, Ramella S, Lanza P, Ranelletti FO. Expression of the RNA-binding protein HuR and its clinical significance in human stage I and II lung adenocarcinoma. Histol Histopathol. 2012 May;27(5):617-26. PubMed PMID:

13: Frau M, Tomasi ML, Simile MM, Demartis MI, Salis F, Latte G, Calvisi DF, Seddaiu MA, Daino L, Feo CF, Brozzetti S, Solinas G, Yamashita S, Ushijima T, Feo F, Pascale RM. Role of transcriptional and posttranscriptional regulation of
methionine adenosyltransferases in liver cancer progression. Hepatology. 2012 Jul;56(1):165-75. doi: 10.1002/hep.25643. Epub 2012 Jun 5. PubMed PMID: 22318685.

14: Kim GY, Lim SJ, Kim YW. Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. Mod Pathol. 2011 Oct;24(10):1336-47. doi: 10.1038/modpathol.2011.90. Epub 2011 May 13. PubMed PMID: 21572400.

15: Ronkainen H, Vaarala MH, Hirvikoski P, Ristimäki A. HuR expression is a marker of poor prognosis in renal cell carcinoma. Tumour Biol. 2011 Jun;32(3):481-7. doi: 10.1007/s13277-010-0141-6. Epub 2010 Dec 16. PubMed PMID: 21161467.

16: Wang J, Wang B, Bi J, Zhang C. Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer. Med Oncol. 2011 Dec;28 Suppl 1:S577-85. doi: 10.1007/s12032-010-9734-6. Epub 2010 Nov 3. PubMed  PMID: 21046284.

17: Cha JD, Li S, Cha IH. Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. Head Neck. 2011 May;33(5):627-37. doi: 10.1002/hed.21507. Epub 2010
Oct 19. PubMed PMID: 20960565.

18: Richards NG, Rittenhouse DW, Freydin B, Cozzitorto JA, Grenda D, Rui H, Gonye G, Kennedy EP, Yeo CJ, Brody JR, Witkiewicz AK. HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected
pancreatic ductal adenocarcinoma patients. Ann Surg. 2010 Sep;252(3):499-505; discussion 505-6. doi: 10.1097/SLA.0b013e3181f1fd44. PubMed PMID: 20739850.

19: Mrena J, Wiksten JP, Kokkola A, Nordling S, Ristimäki A, Haglund C. COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer. Tumour Biol. 2010 Jan;31(1):1-7. doi:
10.1007/s13277-009-0001-4. Epub 2009 Dec 18. PubMed PMID: 20237896.

20: Brennan SE, Kuwano Y, Alkharouf N, Blackshear PJ, Gorospe M, Wilson GM. The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. Cancer Res. 2009 Jun
15;69(12):5168-76. doi: 10.1158/0008-5472.CAN-08-4238. Epub 2009 Jun 2.  PMID: 19491267; PubMed Central PMCID: PMC2724875.

21: Wang J, Zhao W, Guo Y, Zhang B, Xie Q, Xiang D, Gao J, Wang B, Chen Z. The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis.
Oncology. 2009;76(6):420-9. doi: 10.1159/000216837. Epub 2009 May 5. PubMed PMID:19420963.

22: Yi X, Zhou Y, Zheng W, Chambers SK. HuR expression in the nucleus correlates with high histological grade and poor disease-free survival in ovarian cancer. Aust N Z J Obstet Gynaecol. 2009 Feb;49(1):93-8. doi:
10.1111/j.1479-828X.2008.00937.x. PubMed PMID: 19281587.

23: Yoo PS, Sullivan CA, Kiang S, Gao W, Uchio EM, Chung GG, Cha CH. Tissue microarray analysis of 560 patients with colorectal adenocarcinoma: high expression of HuR predicts poor survival. Ann Surg Oncol. 2009 Jan;16(1):200-7.
doi: 10.1245/s10434-008-0209-3. Epub 2008 Nov 14. PubMed PMID: 19009247.

24: Niesporek S, Kristiansen G, Thoma A, Weichert W, Noske A, Buckendahl AC, Jung K, Stephan C, Dietel M, Denkert C. Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2
expression. Int J Oncol. 2008 Feb;32(2):341-7. PubMed PMID: 18202756.

25: Heinonen M, Fagerholm R, Aaltonen K, Kilpivaara O, Aittomäki K, Blomqvist C, Heikkilä P, Haglund C, Nevanlinna H, Ristimäki A. Prognostic role of HuR in hereditary breast cancer. Clin Cancer Res. 2007 Dec 1;13(23):6959-63. PubMed
PMID: 18056170.

26: Leandersson K, Riesbeck K, Andersson T. Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells. Nucleic Acids  2006;34(14):3988-99. Epub 2006 Aug 12. PubMed PMID: 16914445; PubMed Central
PMCID: PMC1557823.

27: Denkert C, Koch I, von Keyserlingk N, Noske A, Niesporek S, Dietel M, Weichert W. Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. Mod Pathol. 2006 Sep;19(9):1261-9. Epub 2006 Jun 23. PubMed PMID: 16799479.

28: Mrena J, Wiksten JP, Kokkola A, Nordling S, Haglund C, Ristimäki A. Prognostic significance of cyclin A in gastric cancer. Int J Cancer. 2006 Oct15;119(8):1897-901. PubMed PMID: 16708383.

29: Mrena J, Wiksten JP, Thiel A, Kokkola A, Pohjola L, Lundin J, Nordling S, Ristimäki A, Haglund C. Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability
factor HuR. Clin Cancer Res. 2005 Oct 15;11(20):7362-8. PubMed PMID: 16243808.

30: Heinonen M, Bono P, Narko K, Chang SH, Lundin J, Joensuu H, Furneaux H, Hla T, Haglund C, Ristimäki A. Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Res. 2005 Mar 15;65(6):2157-61. PubMed
PMID: 15781626.

31: Denkert C, Weichert W, Pest S, Koch I, Licht D, Köbel M, Reles A, Sehouli J, Dietel M, Hauptmann S. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. Cancer Res. 2004 Jan 1;64(1):189-95. PubMed PMID: 14729623

32: McAllister F, Pineda DM, Jimbo M, Lal S, Burkhart RA, Moughan J, Winter KA, Abdelmohsen K, Gorospe M, Acosta Ade J, Lankapalli RH, Winter JM, Yeo CJ, Witkiewicz AK, Iacobuzio-Donahue CA, Laheru D, Brody JR. dCK expression
correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial. Cancer Biol Ther. 2014 Jun 1;15(6):688-98. doi: 10.4161/cbt.28413. Epub 2014 Mar 11. PubMed PMID: 24618665; PubMed Central PMCID: PMC4049785.