A Tool to Change Human Antigen R Protein Expression: May Have Implications in both Cancer & Diabetes >

 

Copyright © 2014 by Dr. Kerry Masterson  ·  All Rights reserved  ·  E-Mail: km@humanantigenr.com
 
 

  HuR: A Cancer and Diabetes Target          HuR mRNA Protective Sequence (HPS)           HPS Experiment Results          Contact
Human Antigen R mRNA Protective Sequence Site
 
PubMed search for HuR AND Glioma

1: Wang L, Wei B, Hu G, Wang L, Jin Y, Sun Z. Gene expression analyses to explore the biomarkers and therapeutic targets for gliomas. Neurol Sci. 2014 Oct 28. [Epub ahead of print] PubMed PMID: 25348135.

2: Suswam EA, Shacka JJ, Walker K, Lu L, Li X, Si Y, Zhang X, Zheng L, Nabors LB, Cao H, King PH. Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth. J Neurooncol. 2013 Jun;113(2):195-205. doi: 10.1007/s11060-013-1112-8. Epub 2013 Mar 25. PubMed PMID: 23525947; PubMed Central PMCID: PMC3679321.

3: Filippova N, Yang X, King P, Nabors LB. Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function. J Biol Chem. 2012  Sep 14;287(38):32277-87. doi: 10.1074/jbc.M112.353912. Epub 2012 Jul 24. PubMed PMID: 22829587; PubMed Central PMCID: PMC3442558.

4: Bolognani F, Gallani AI, Sokol L, Baskin DS, Meisner-Kober N. mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells. J Neurooncol. 2012 Feb;106(3):531-42. doi: 10.1007/s11060-011-0707-1. Epub
2011 Sep 21. PubMed PMID: 21935689.

5: Filippova N, Yang X, Wang Y, Gillespie GY, Langford C, King PH, Wheeler C, Nabors LB. The RNA-binding protein HuR promotes glioma growth and treatment resistance. Mol Cancer Res. 2011 May;9(5):648-59. doi: 10.1158/1541-7786.MCR-10-0325. Epub 2011 Apr 15. PubMed PMID: 21498545; PubMed Central PMCID: PMC3096748.

6: Spooren A, Mestdagh P, Rondou P, Kolmus K, Haegeman G, Gerlo S. IL-1β potently stabilizes IL-6 mRNA in human astrocytes. Biochem Pharmacol. 2011 Apr 15;81(8):1004-15. doi: 10.1016/j.bcp.2011.01.019. Epub 2011 Feb 12. PubMed PMID: 21300032.

7: Lu L, Wang S, Zheng L, Li X, Suswam EA, Zhang X, Wheeler CG, Nabors LB, Filippova N, King PH. Amyotrophic lateral sclerosis-linked mutant SOD1 sequestersHu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired
post-transcriptional regulation of vascular endothelial growth factor. J Biol Chem. 2009 Dec 4;284(49):33989-98. doi: 10.1074/jbc.M109.067918. Epub 2009 Oct 5.PubMed PMID: 19805546; PubMed Central PMCID: PMC2797169.

8: Suswam E, Li Y, Zhang X, Gillespie GY, Li X, Shacka JJ, Lu L, Zheng L, King PH. Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Res. 2008 Feb 1;68(3):674-82. doi:
10.1158/0008-5472.CAN-07-2751. PubMed PMID: 18245466.

9: Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, King PH. Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR. Cancer Res. 2003 Jul 15;63(14):4181-7. PubMed
PMID: 12874024.