A Tool to Change Human Antigen R Protein Expression: May Have Implications in both Cancer & Diabetes >


Copyright © 2014 by Dr. Kerry Masterson  ·  All Rights reserved  ·  E-Mail: km@humanantigenr.com

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Human Antigen R mRNA Protective Sequence Site
Angiogenesis signals related to HuR protien expression.


PubMed search for HUR AND Angiogenisis

1: Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18309-14. doi: 10.1073/pnas.1412172111.
Epub 2014 Nov 24. PubMed PMID: 25422430.

2: Dong R, Yang GD, Luo NA, Qu YQ. HuR: a promising therapeutic target for angiogenesis. Gland Surg. 2014 Aug;3(3):203-6. doi: 10.3978/j.issn.2227-684X.2014.03.02. Review. PubMed PMID: 25207213; PubMed Central PMCID: PMC4139128.

3: Griseri P, Pagès G. Control of pro-angiogenic cytokine mRNA half-life in cancer: the role of AU-rich elements and associated proteins. J Interferon Cytokine Res. 2014 Apr;34(4):242-54. doi: 10.1089/jir.2013.0140. Review. PMID: 24697202.

4: Chang SH, Hla T. Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis. Curr Opin Hematol. 2014 May;21(3):235-40. doi:10.1097/MOH.0000000000000040. Review. PubMed PMID: 24714527.

5: Chang SH, Lu YC, Li X, Hsieh WY, Xiong Y, Ghosh M, Evans T, Elemento O, Hla T.Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis. J Biol Chem. 2013 Feb 15;288(7):4908-21. doi: 10.1074/jbc.M112.423871. Epub 2012 Dec 6. PubMed PMID: 23223443; PubMed Central PMCID: PMC3576095.

6: Lu YC, Chang SH, Hafner M, Li X, Tuschl T, Elemento O, Hla T. ELAVL1 Modulates Transcriptome-wide miRNA Binding in Murine Macrophages. Cell Rep. 2014 Dec 24;9(6):2330-43. doi: 10.1016/j.celrep.2014.11.030. Epub 2014 Dec 18. PubMed
PMID: 25533351; PubMed Central PMCID: PMC4277505.

7: Miyata Y, Watanabe S, Sagara Y, Mitsunari K, Matsuo T, Ohba K, Sakai H. High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer. PLoS One. 2013;8(3):e59095. doi:
10.1371/journal.pone.0059095. Epub 2013 Mar 13. PubMed PMID: 23516604; PubMed Central PMCID: PMC3596286.

8: Tong X, Mirzoeva S, Veliceasa D, Bridgeman BB, Fitchev P, Cornwell ML, Crawford SE, Pelling JC, Volpert OV. Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and
thrombospondin-1. Oncotarget. 2014 Nov 30;5(22):11413-27. PubMed PMID: 25526033.

9: Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR. Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis.
Am J Pathol. 2012 Apr;180(4):1751-60. doi: 10.1016/j.ajpath.2011.12.025. Epub 2012 Feb 7. PubMed PMID: 22322302; PubMed Central PMCID: PMC3349897.

10: Gubin MM, Calaluce R, Davis JW, Magee JD, Strouse CS, Shaw DP, Ma L, Brown A, Hoffman T, Rold TL, Atasoy U. Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient
angiogenesis. Cell Cycle. 2010 Aug 15;9(16):3337-46. doi: 10.4161/cc.9.16.12711. Epub 2010 Aug 17. PubMed PMID: 20724828; PubMed Central PMCID: PMC3041167.

11: Pullmann R Jr, Rabb H. HuR and other turnover- and translation- RNA-binding proteins: implications for the kidney. Am J Physiol Renal Physiol. 2014 Mar 15;306(6):F569-76. doi: 10.1152/ajprenal.00270.2013. Epub 2014 Jan 15.
Review. PubMed PMID: 24431206.

12: Roche E, Lascombe I, Bittard H, Mougin C, Fauconnet S. The PPARβ agonist L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a receptor-independent mechanism. Cell Signal. 2014 Feb;26(2):433-43. doi: 10.1016/j.cellsig.2013.10.006. Epub 2013 Oct 28. PubMed PMID: 24172859.

13: Suswam EA, Shacka JJ, Walker K, Lu L, Li X, Si Y, Zhang X, Zheng L, Nabors LB, Cao H, King PH. Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth. J Neurooncol. 2013 Jun;113(2):195-205. doi: 10.1007/s11060-013-1112-8. Epub 2013 Mar 25. PubMed PMID: 23525947; PubMed Central PMCID: PMC3679321.

14: Lee SH, Ju SK, Lee TY, Huh SH, Han KH. TIP30 directly binds p53 tumor suppressor protein in vitro. Mol Cells. 2012 Nov;34(5):495-500. doi: 10.1007/s10059-012-0232-x. Epub 2012 Nov 15. PubMed PMID: 23178973;  PMCID: PMC3887794.

15: Cho SJ, Jung YS, Zhang J, Chen X. The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation. J Biol Chem. 2012 Apr 27;287(18):14535-44. doi:
10.1074/jbc.M111.326827. Epub 2012 Feb 27. PubMed PMID: 22371495; PubMed Central PMCID: PMC3340227.

16: Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol. 2012 Mar;32(5):929-40. doi: 10.1128/MCB.05921-11. Epub 2012 Jan 3. PubMed PMID: 22215620; PubMed Central PMCID: PMC3295200.

17: Miyashita H, Watanabe T, Hayashi H, Suzuki Y, Nakamura T, Ito S, Ono M, Hoshikawa Y, Okada Y, Kondo T, Sato Y. Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1.
PLoS One. 2012;7(10):e46459. doi: 10.1371/journal.pone.0046459. Epub 2012 Oct 8. PubMed PMID: 23056314; PubMed Central PMCID: PMC3466306.

18: Sun L, Zhang S, Jiang Z, Huang X, Wang T, Huang X, Li H, Zhang L. Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-α-treated A549 cells. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):99-105. doi:
10.1016/j.bbrc.2011.11.004. Epub 2011 Nov 10. PubMed PMID: 22093832.

19: Wang J, Wang B, Bi J, Zhang C. Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer. Med Oncol.  Dec;28 Suppl 1:S577-85. doi: 10.1007/s12032-010-9734-6. Epub 2010 Nov 3. PubMed PMID: 21046284.

20: Annabi B, Lachambre MP, Plouffe K, Moumdjian R, Béliveau R. Propranololadrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion. Pharmacol Res. 2009 Nov;60(5):438-45. doi:
10.1016/j.phrs.2009.05.005. Epub 2009 May 23. PubMed PMID: 19467330.

21: Kurosu T, Ohga N, Hida Y, Maishi N, Akiyama K, Kakuguchi W, Kuroshima T, Kondo M, Akino T, Totsuka Y, Shindoh M, Higashino F, Hida K. HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium.
Br J Cancer. 2011 Mar 1;104(5):819-29. doi: 10.1038/bjc.2011.20. Epub 2011 Feb 1. PubMed PMID: 21285980; PubMed Central PMCID: PMC3048211.

22: Chae KS, Kang MJ, Lee JH, Ryu BK, Lee MG, Her NG, Ha TK, Han J, Kim YK, Chi SG. Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions. Oncogene. 2011 Mar 10;30(10):1213-28. doi:
10.1038/onc.2010.498. Epub 2010 Nov 8. PubMed PMID: 21057546.

23: Basu A, Datta D, Zurakowski D, Pal S. Altered VEGF mRNA stability following treatments with immunosuppressive agents: implications for cancer development. J Biol Chem. 2010 Aug 13;285(33):25196-202. doi: 10.1074/jbc.M110.119446. Epub 2010 Jun 16. PubMed PMID: 20554520; PubMed Central PMCID: PMC2919082.

24: Yoo PS, Sullivan CA, Kiang S, Gao W, Uchio EM, Chung GG, Cha CH. Tissue microarray analysis of 560 patients with colorectal adenocarcinoma: high expression of HuR predicts poor survival. Ann Surg Oncol. 2009 Jan;16(1):200-7.
doi: 10.1245/s10434-008-0209-3. Epub 2008 Nov 14. PubMed PMID: 19009247.

25: Abdelmohsen K, Gorospe M. Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA. 2010 Sep-Oct;1(2):214-29. doi: 10.1002/wrna.4. Epub 2010 May 6. Review. PubMed PMID: 21935886; PubMed Central PMCID: PMC3808850.

26: Suswam E, Li Y, Zhang X, Gillespie GY, Li X, Shacka JJ, Lu L, Zheng L, King PH. Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Res. 2008 Feb 1;68(3):674-82. doi:
10.1158/0008-5472.CAN-07-2751. PubMed PMID: 18245466.

27: Brennan SE, Kuwano Y, Alkharouf N, Blackshear PJ, Gorospe M, Wilson GM. The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. Cancer Res. 2009 Jun
15;69(12):5168-76. doi: 10.1158/0008-5472.CAN-08-4238. Epub 2009 Jun 2. PubMed PMID: 19491267; PubMed Central PMCID: PMC2724875.

28: Avivi A, Shams I, Joel A, Lache O, Levy AP, Nevo E. Increased blood vessel density provides the mole rat physiological tolerance to its hypoxic subterranean habitat. FASEB J. 2005 Aug;19(10):1314-6. Epub 2005 Jun 13. PubMed PMID:

29: Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, King PH. Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR. Cancer Res. 2003 Jul 15;63(14):4181-7. PubMed PMID: 12874024.

30: Lejbkowicz F, Goldberg-Cohen I, Levy AP. New horizons for VEGF. Is there a role for nuclear localization? Acta Histochem. 2005;106(6):405-11. Epub 2005 Jan 13. PubMed PMID: 15707649.

31: Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J, Lamarre J,Feige JJ. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene. 2004 Nov 11;23(53):8673-80. PubMed PMID:15467755.

32: Ido K, Nakagawa T, Sakuma T, Takeuchi H, Sato K, Kubota T. Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human astrocytic tumors. Neuropathology. 2008 Dec;28(6):604-11. doi: 10.1111/j.1440-1789.2008.00926.x. Epub 2008 May 21. PubMed PMID: 18498284.

36: Dixon DA, Tolley ND, King PH, Nabors LB, McIntyre TM, Zimmerman GA, Prescott SM. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Invest. 2001 Dec;108(11):1657-65. PubMed PMID: 11733561; PubMed Central PMCID: PMC200983.

37: Levy NS, Chung S, Furneaux H, Levy AP. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem. 1998 Mar 13;273(11):6417-23. PubMed PMID: 9497373.

38: Levy AP. Hypoxic regulation of VEGF mRNA stability by RNA-binding proteins.Trends Cardiovasc Med. 1998 Aug;8(6):246-50. PubMed PMID: 14987559.

39: Nabors LB, Gillespie GY, Harkins L, King PH. HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs. Cancer Res. 2001 Mar 1;61(5):2154-61. PubMed PMID: 11280780.

40: Datta  K, Mondal S, Sinha S, Li J, Wang E, Knebelmann B, Karumanchi SA, Mukhopadhyay D. Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma. Oncogene. 2005 Nov 24;24(53):7850-8. PubMed PMID: 16170373.

41: Onesto C, Berra E, Grépin R, Pagès G. Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA. J Biol Chem. 2004 Aug 13;279(33):34217-26. Epub 2004 Jun 2. PubMed PMID: 15175342.

42: Annabi B, Currie JC, Moghrabi A, Béliveau R. Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg. Leuk Res. 2007 Sep;31(9):1277-84. Epub 2006 Nov 1. PubMed PMID: 17081606.

43: Yoo PS, Mulkeen AL, Cha CH. Post-transcriptional regulation of vascular endothelial growth factor: implications for tumor angiogenesis. World J Gastroenterol. 2006 Aug 21;12(31):4937-42. Review. PubMed PMID: 16937487; PubMed
Central PMCID: PMC4087394.

44: Goldberg-Cohen I, Furneauxb H, Levy AP. A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR. J Biol Chem. 2002 Apr 19;277(16):13635-40. Epub 2002 Feb 7. PubMed PMID: 11834731.